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BCMA

Researchers are currently investigating BCMA as a possible target in Multiple Myeloma.1,2

 

One of the new areas of research includes studying BCMA.1,2 BCMA is a protein shared by all people with Multiple Myeloma1,2 and what makes them more like a family. BCMA can be found on healthy plasma cells and cancerous myeloma cells. BCMA contributes to the growth and proliferation of myeloma cells.1,2 That's why BCMA is a key focus in clinical trials, as a potential target in Multiple Myeloma.1,2

Researchers are investigating the potential of targeting BCMA.1,7

Research

Ongoing research is critical to help support people living with Multiple Myeloma. 

 

There are various BCMA-targeting strategies currently under investigation for Multiple Myeloma.

 

The safety and effectiveness of these strategies are unknown.

ADCs

 

Antibody-drug conjugates (ADCs)1,8,9


There are a lot of ADCs in research right now across several tumor types.1,8,9 In fact, more than 100 clinical trials have tested the safety and effectiveness of ADCs for a variety of targets, including BCMA.1,8,9

 

ADCs are made up of 2 main components: an antibody and the actual medicine.1,8 The antibody targets specific areas on the outside of cells, including cancer cells.1,8,9 This helps the ADC attach to the cancer cell.1,8,9 Once attached, medicine is delivered inside the cancer cell to kill it.1,8,9
 

Bispecific Abs

 

Bispecific antibodies1,10,11


Bispecific antibodies have 2 arms that can attach to 2 different areas at the same time.1,10,11

 

One arm attaches to the body’s T cells.1,10,11 T cells are like soldiers of the immune system.1,10,11 They find and help fight disease.1,10,11

 

The other arm attaches to the cancer cell.1,10,11 This brings the body’s T cells and the cancer cells close together. 1,10,11 That way, the T cells have a better chance of killing the cancer cells.1,10,11
 

CAR T cell

 

Chimeric antigen receptor (CAR) T-cell (CAR T cell)1,11,12


CAR T cell therapy is a personalized type of treatment that uses a patient’s cells to fight cancer.1,11 Specific cells, called T cells, are taken from the blood and then enhanced in a laboratory.1,11,12 Then, the enhanced T cells are put back into the patient’s body so they can attack the cancer cells.1,11,12